Active Immunization with a Glycolipid Transition State Analogue Protects against Endotoxic Shock
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چکیده
منابع مشابه
Interferon β protects against lethal endotoxic and septic shock through SIRT1 upregulation
Lipopolysaccharide (LPS), an endotoxin derived from gram-negative bacteria, promotes the secretion of proinflammatory cytokines and mediates endotoxemia through activation of mitogen activated protein kinases, NF-κB, and interferon regulatory factor-3. Silent information regulator transcript-1 (SIRT1), an NAD-dependent deacetylase, mediates NF-κB deacetylation, and inhibits its function. SIRT1 ...
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1. A single intracutaneous inoculation with a subinfective dose of the virus of poliomyelitis produces considerable immunity. 2. Virus-serum combinations produce an appreciable immunity, providing just sufficient serum is used to protect the animal from paralysis. If there is an excess of serum, the degree of immunity is considerably reduced.
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ژورنال
عنوان ژورنال: Angewandte Chemie International Edition
سال: 2002
ISSN: 1433-7851,1521-3773
DOI: 10.1002/1521-3773(20021115)41:22<4241::aid-anie4241>3.0.co;2-n